Tropomyosin and actin
نویسندگان
چکیده
منابع مشابه
Tropomyosin keeps actin tough
Actin (green) and ADF/cofilin (red) are disorganized in the absence of tropomyosin (bottom). ntracellular parasites must walk a fine line, invading and exploiting a host cell without killing it too quickly. On page 1029, Glomski et al. show how a single amino acid determines not only the pH I optimum of a bacterial hemolysin, but also the virulence of an important pathogen. The data help explai...
متن کاملActin Dynamics: Tropomyosin Provides Stability
Tropomyosin stabilizes actin filaments, while ADF/cofilin promotes their disassembly. These two proteins compete with each other for binding to the actin filament, providing a critical balance for actin assembly in vivo.
متن کاملA small molecule inhibitor of tropomyosin dissociates actin binding from tropomyosin-directed regulation of actin dynamics
The tropomyosin family of proteins form end-to-end polymers along the actin filament. Tumour cells rely on specific tropomyosin-containing actin filament populations for growth and survival. To dissect out the role of tropomyosin in actin filament regulation we use the small molecule TR100 directed against the C terminus of the tropomyosin isoform Tpm3.1. TR100 nullifies the effect of Tpm3.1 on...
متن کاملRegulation of the actin filament by tropomyosin
Tropomyosin (Tm) binds along actin filaments and is a universal regulator of filament function. Mutations cause myopathies and certain forms are down-regulated in cancer cells. In muscle, with troponin Tm makes contraction Ca2+-dependent. In non-muscle cells Tm stabilizes actin filaments and protects them from branching, severing and most crosslinking. Tropomyosins enhance formin-nucleated poly...
متن کاملThe binding dynamics of tropomyosin on actin.
We discuss a theoretical model for the cooperative binding dynamics of tropomyosin to actin filaments. Tropomyosin binds to actin by occupying seven consecutive monomers. The model includes a strong attraction between attached tropomyosin molecules. We start with an empty lattice and show that the binding goes through several stages. The first stage represents fast initial binding and leaves ma...
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ژورنال
عنوان ژورنال: Nature
سال: 1975
ISSN: 0028-0836,1476-4687
DOI: 10.1038/257827c0